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These pigments can accumulate and cause a darkened appearance
(4) A.S.Rssler, J.G.Pfaus, H.K.Kia, et al (2006) The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat Pharmacology, Biochemistry, and Behaviour, Volume 85, Issue 3, November 2006, Pages 514-521