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Subsequent laboratory studies have explored its observed effects on senescent chondrocytes, endothelial cell senescence via p53 signaling, and senescent cancer-cell models

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With these points in mind, we undertook a broad assessment of published clinical data, curating the body weight loss (% from baseline), glycosylated hemoglobin levels (HbA1c), and nausea responses (% patients reporting) from the SUSTAIN 3, SUSTAIN 7, SCALE Diabetes, SURPASS 2, and STEP 2 trials (64, 66, 67) ( Figures 1AC )

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