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These effects are observed in experimental settings, but there is no established safe dose for human use from clinical trials
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GLP-1RAs can cross the bloodbrain barrier and activate brain GLP-1 receptors, leading to neuroprotection by improving insulin signaling, reducing tau hyperphosphorylation, and enhancing cognitive function in diabetic and aging models
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If severe nausea persists with each dose, discontinuation is advisable
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