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TRIUMPH-3 (NCT05882045) Design: Phase 3, 80-week, randomised, double-blind, placebo-controlled trial in adults with severe obesity (Class 2 or 3, BMI 35) and established cardiovascular disease, with or without type 2 diabetes
What This Means If you're on a GLP-1 medication, this study underscores one critical truth: Continuity matters more than you think
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
The tradeoffs are equally real: weekly injection, $900+ per month without insurance, limited supply relative to demand, and side effects that affect a substantial portion of users nausea, vomiting, constipation, and GI disruption are among the most common, particularly during dose escalation
Non-melanoma skin cancers are rarely fatal, however, they can grow if not treated early and result in substantial destruction of local tissue and disfigurement
