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Participants receiving tirzepatide reached a 20.2% mean weight reduction at 72 weeks, whereas the semaglutide group lost 13.7%

JAMA Cardiol 2(12):13151321 Arnold SV, Stone GW, Mack MJ, Chhatriwalla AK, Austin BA, Zhang Z et al (2020) Health status changes and outcomes in patients with heart failure and mitral regurgitation: COAPT Trial

This indicates a higher likelihood of meaningful improvement in desire and associated distress

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