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While the principles regulating glucose-dependence in cancer cells have been extensively reviewed, we still do not fully understand how cancer cells use many of the metabolic strategies to contribute to core metabolic functions in the presence of nutrients different from glucose
Nervous system disorders Uncommon: Headache Not known: Convulsions*, Dizziness Heart disease Not known: Palpitations Vascular pathologies Uncommon: Hypertension, Hypotension Respiratory, thoracic and mediastinal pathologies Not known: Dyspnea Gastrointestinal disorders Common: Vomiting, Nausea, Diarrhea, Abdominal pain Uncommon: Dysgeusia, Dyspepsia, Dry mouth Skin and subcutaneous tissue disorders Uncommon: Abnormal skin odor ** Not known: Itching, Skin rash Musculoskeletal and connective tissue disorders Uncommon: Muscle spasms Not known: Myasthenia***, Muscle tension Systemic disorders and conditions related to the administration site Uncommon: Chest pain, Feeling abnormal, Pyrexia, Injection site reaction**** Diagnostic tests Uncommon: Increased blood pressure Very rare: Increased INR*****
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SCFAs: short-chain fatty acids Gut microbial metabolites generated from LC, such as SCFAs, act as signaling molecules, regulating host immunity and metabolism
The incretin effect refers to the bodys stronger insulin response to oral glucose as compared to intravenous glucose at the same blood sugar level ( [26] ) ( [27] )
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