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They prided themselves on eating healthy and yet found they had become fatter, diabetic, or pre-diabetic despite doing everything right. They were telling their patients to eat low-fat diets, mostly plants, not too much (control their portion sizes), and to exercise
Tirzepatide, a single peptide that binds to both GLP-1 and GIP receptors, was approved by the FDA in 2022 to treat type 2 diabetes
As a result of these findings, the collaborators suggested 'proglucagon 78-107 may be the incretin of the lower gut' (Holst, rskov, Vagn Nielsen, Schwartz)
Melanotan 2 is a generalist: it activates MC1, MC3, MC4, and MC5, making it a tool for studying melanogenesis via the MC1R, but with a broad signature
Some of the key areas of focus for future research include: Looking into semaglutides use in patients who have had different surgeries Studying semaglutides benefits in non-diabetic patients who have had surgery Checking the long-term safety and effectiveness of semaglutide in post-surgical patients As research keeps growing, healthcare providers will be able to make better decisions about semaglutide for post-surgical patients
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