Key points Emerging therapies for Parkinson disease (PD) have focused largely on disease modification and on dopamine resistance symptoms, which are both important unmet needs
These changes usually start within three months of a stressful event
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In addition to worsening symptoms such as headache, dizziness, and vomiting mentioned above, ataxia, mental confusion, varying degrees of consciousness disorders, fever, and in severe cases, brain herniation can occur, endangering life (Li et al., 2023).The exact pathophysiological mechanisms underlying the development of AMS and HACE have not been fully determined
Additionally, ROS activates proinflammatory mediators, NRLP3 inflammasomes, and proatherogenic transcription factors