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5-Amino-1MQ is a first-in-class small molecule inhibitor designed to target Nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that acts as a master regulator of the cellular "metabolic drain."

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The published phase 2 trial studied five once-weekly doses: 0.3, 0.6, 1.2, 2.4 and 4.5 mg