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The intracellular glutathione pool is regulated by a series of enzymes involved in its synthesis, utilization and recycling, and high expression levels of these genes have been seen to promote cisplatin resistance in lung adenocarcinoma cell lines, with the glutamate cysteine ligase catalytic subunit (GCLC) expression being proposed as a potential predictor of treatment failure 30

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8 Reduction or deletion of GGT1 expression does not impair GSH-mediated rescue of cells in cystine-free conditions