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[2] [5] High doses of acetaminophen are known to deplete endogenous glutathione stores, particularly in the liver, which may increase the risk of toxicity
In diabetes and its complications, chronic hyperglycemia accelerates oxidative stress, leading to neuropathy, nephropathy, and retinopathy
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[25] [26] [27] Metabolism [edit] Among the many metabolic processes in which it participates, glutathione is required for the biosynthesis of leukotrienes and prostaglandins
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