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A recent study of hepatocellular carcinoma published by Kuangs laboratory revealed that pericancerous macrophages cross-present antigens to CD103 + cytotoxic T lymphocytes to result in their retention in the pericancerous area, thus inducing the activity of cytotoxic T cells to exert protumorigenic effects and resistance to PD-1-directed immunotherapy [115]
It found that saxagliptin significantly increased the risk of HF by 21%, especially in patients at high risk for cardiovascular, while no signal was detected for other DPP4i
Other important safety considerations include the risk of gallbladder disease, acute kidney injury associated with severe gastrointestinal adverse events, and potential worsening of diabetic retinopathy, particularly with rapid improvement in glycemic control
Additionally, certain medications and treatments could affect glutathione levels
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