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Current Areas of Scientific Investigation While there are not current studies evaluating the combination of methionine, choline, carnitine, and dexpanthenol, there are studies evaluating individual ingredients

Pharmacokinetic and endpoint data from human studies does not transfer to an in vitro system or to a rodent model, and the receptor-level measurements that do transfer are a small fraction of the total citation volume

The authors hypothesize that this paradoxical worsening is due to a cytokine imbalance, similar to what is seen with the exacerbation of disease after administration of biological treatments like anti-TNF, which increases interferon (IFN)- release and leukocyte chemotaxis [25]

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