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This could lead to a form of jaundice-induced brain damage called kernicterus, a rare disorder in which bilirubin is deposited in the brain, leading to vision and hearing loss that can be permanent.56 Likewise, children under 18 should not take berberine supplements

However, side effects such as temporary swelling, allergic reaction, and interactions with other medications are possible

Some laboratory studies and theories suggest that high-dose vitamin C may create an environment that is challenging to cancer cells

Rasic D, Drmic D, Sever M, Baric M, Grgic T, et al

Figure 2 For the treatment of AALI (APAP-associated ALI), only NAC has been used as a classic therapy for APAP-associated hepatotoxicity induced by NAPQI