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In 2025, Wegovy was given additional FDA approval for treating a liver disease known as metabolic dysfunction-associated steatohepatitis (MASH), which causes inflammation, scarring, and fat deposits in the liver
exenatide, lixisenatide) were designed to resist DPP-4 metabolism, and had half-lives of ~3hrs necessitating twice-daily or daily dosing
Clinicians should review medication lists and consider potential interactions when assessing muscle loss risk in patients initiating semaglutide
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The evidence suggests that tirzepatides dual-receptor mechanism offers enhanced weight loss and metabolic benefits for many patients
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