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If youre on semaglutide for weight loss only (no diabetes, normal A1C), metformin isnt typically added because the marginal weight loss benefit is small in non-diabetic patients
Symptoms I Pay Attention To Unusual fatigue Rapid heart rate New digestive issues Anxiety or restlessness Drastic changes in hunger Red Flags Patients Often Ignore Feeling extremely cold Consistent brain fog Dramatic hair shedding No weight loss after 12+ weeks These can signal dose adjustments for thyroid medication, not a problem with GLP-1
GLP-1 medications follow a dose-response relationship, meaning higher doses generally produce stronger metabolic effects
clinical presentation Onset is gradual and subacute, over several days
Second-generation non-peptidic oral GLP1RAs promise to extend the benefits of GLP1 therapy to those who do not want, or cannot have, subcutaneous injection therapy
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