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Exploratory outcomes included changes in waist circumference, systolic-type blood pressure, and NT-proBNP levels

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Physicians in charge decided plasma sampling to measure plasma VPA concentrations, treatments and L-carnitine dose regimen, which included an intravenous 100 mg/kg loading dose followed by a maintenance dosing up to 3 g/day in 3 divided doses for 3 days (or until ICU discharge)

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Eric Ravussin, LSU Boyd Professor and one of the study's lead researchers, emphasized the potential implications of these findings, "Our research indicates that tirzepatide not only facilitates substantial weight loss but also enhances fat oxidation, but unfortunately, did not decrease the metabolic adaptation usually seen with weight loss