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This analysis demonstrated a bifurcating pseudotime trajectory, including a maturation process (trajectory A) and a proliferation process (trajectory B)

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The oral bioavailability and blood-brain barrier penetration are what distinguish Dihexa from most neuropeptides (which require intranasal or IV delivery)

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Semaglutide overcomes this through two structural modifications: an alanine-to-Aib substitution at position 8 (which removes the DPP-4 cleavage site) and the attachment of a C18 fatty diacid chain via a bifunctional linker at lysine position 26