Serious Side Effects and Sequelae Acute Pancreatitis: Severe abdominal pain and persistent vomiting, requiring emergency treatment.Gallbladder Disease: Gallstone formation, right upper quadrant pain, and indigestion.Cardiocardiac Problems: Irregular heartbeat, palpitations, or abnormal blood pressure.Severe Allergic Reactions: Difficulty breathing, Facial swelling, generalized rash Mood changes: Depression, anxiety, suicidal tendencies (reported rate 1-5%) Long-term risks: Thyroid C-cell tumor: Warning in animal studies, indicated by a black border on the packaging Deteriorating kidney function: Increased renal burden for long-term users Recurrence of pancreatitis: Increased risk of recurrent attacks Weight rebound: Rapid return to original weight within months of discontinuation Nutritional imbalance: Appetite suppression leading to vitamin and mineral deficiencies Pre- and post-use management Before use: Check liver and kidney function and baseline blood glucose

Whilst orlistat works locally in the gut with minimal systemic absorption, Wegovy is absorbed into the bloodstream and acts centrally on the brain's appetite regulation centres, as well as slowing gastric emptying
The bottom line on formulations If you are breastfeeding and your physician approves GLP-1 therapy, only injectable formulations should be considered
Tirzepatide is the first and only GLP-1 and glucose-dependent insulinotropic peptide (GIP) agonist approved by the FDA for the treatment of diabetes and obesity [11,12]
This led to the development of tirzepatide (Mounjaro and Zepbound, which is a slightly higher dose)