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When weight loss occurs rapidly, the fat compartments of the face can diminish faster than the skins collagen network can adapt

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Given the known side effects of GLP-1s such as intestinal discomfort and muscle loss, most people have trouble staying on them for more than a year and the weight loss is often reversed once they stop

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In clinical trials involving 17,183 patients, 50.2% of participants treated with GLP-1 receptor agonists lost at least 5% of their body weight, and 17.5% achieved a weight loss of 10% or more, both figures being significant compared to a placebo group