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Litwack G, Ketterer B and Arias IM
Incretins such as GLP1 receptor agonists work by stimulating insulin and inhibiting glucagon release
Results showed that in PA-treated HUVECs and HFD-fed ApoE / mice, combination of metformin and liraglutide at lower dose significantly improved endothelial dysfunction compared with the single treatment
In the presence of reduced metals (iron, copper), antioxidants like flavonoids can generate toxic ROS instead of protecting cells
Green MD, Shires TK, Fischer LJ
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