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In the present analysis, 5 rodent studies reported the IL-1 titres in serum and/or tissue and the mean total of a subgroup of the diabetic group with 20 animals was 57.42 pg/ml and the matching mean total in the healthy control was 34.115 pg/ml, which indicates an increase of 68.31% between the two treatment groups ( Supplementary Figure S1-27

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GSH + amino acid -Glu-amino acid +CysH-Gly (amino group transfer) GSH + H2O Glu +CysH-Gly (hydrolysis) GSH + GSH -Glu-GSH +CysH-Gly (amino group transfer) 3

The resultant files were processed with El-Maven (Elucidata) alongside the Kyoto Encyclopedia of Genes and Genomes (KEGG) 20,21,22 database for metabolite assignment and manual peak integration as previously described using intact mass, isotopic patterns, and an in-house standard library 23

This pharmaceutical-grade compound is intended exclusively for qualified researchers and laboratory use