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Reported readouts include integrin and TGF-linked regulation, changes in MMP-2 and extracellular-matrix turnover, and shifts in antioxidant and inflammatory-response elements in cell and animal models

Following the generation of H 2 O 2 within the mitochondrial matrix it diffuses into the cytosol where it is eliminated by several antioxidant enzymes that include glutathione peroxidases (GPx1GPx8), catalase, and peroxiredoxins (PRDX1PRDX6)