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Research parameters include angiogenic signaling, growth-factor expression, nitric oxide pathway activity, peptide stability, and formulation-dependent transport characteristics

Anal Chim Acta 711:716 Thulin P, Nordahl G, Gry M, Yimer G, Aklillu E, Makonnen E, Aderaye G, Lindquist L, Mattsson CM, Ekblom B, Antoine DJ, Park BK, Linder S, Harrill AH, Watkins PB, Glinghammar B, Schuppe-Koistinen I (2014) Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

Both of these peptides stimulate growth hormone release, both can lower body fat, body weight, and increase muscle mass

Ethics declarations Ethics The study protocol was approved by the Institutional Ethics Committee (IECPG/98/2/2020) of the All India Institute of Medical Sciences (AIIMS), New Delhi, India

Increased pituitary GH raises IGFI, which then affects the gonadal axis