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Expression of ACC1 predominates in the liver, whereas, expression of ACC2 predominates in tissues with a high oxidative capacity

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In animal studies, SGLT2 inhibitors were generally safe during the first trimester but exposure during postnatal day 21 to 90 in juvenile rats, a period coinciding with the late second and third trimester of human renal development, caused dilatation of the renal pelvis and tubules