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Pregnancy represents a special population due its physiologic changes affecting drug and toxin absorption, distribution, metabolism, excretion, and transplacental passage with potential fetal effects
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Cominal JG, Cacemiro MdaC, Berzoti-Coelho MG, Pereira IEG, Frantz FG, Souto EX, et al
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It demonstrates selective toxicity toward senescent HUVECs without affecting non-senescent cells
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Meanwhile, Akt/PKB and AMPK signaling were blunted, and FAO was decreased in gastrocnemius muscle, similar changes are seen in alcohol-induced IR
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