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Drotar A, Phelps P, Fall R (1985) Evidence for glutathione peroxidase activities in cultured plant cells
A lack of antioxidants, and with it glutathione, exacerbates this damage, causing scarring of the tissue and an even more serious condition called cirrhosis
However, such benefits are counterbalanced by risks: P-gp-mediated drug efflux, a key contributor to therapeutic resistance for drugs like MAO inhibitors and anticancer agents, can be modulated by nutraceuticals like PPR and QUE (81, 88)
A well-designed glutathione conjugation strategy considers substrate electrophilicity, the role of the cysteine thiol versus terminal amino or carboxyl groups, protection and deprotection needs, solvent and pH compatibility, oxidation risk, and the downstream analytical question the customer actually needs to answer
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