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Various neurological symptoms with vitamin B12 deficiency and posttreatment evaluation

The constant levels of marker proteins such as GAPDH, combined with observations indicating that knockdown of the UPR element, BiP/Grp78 , revealed no detectable effects on Nrf2, GCLC, or glutathione, further support the conclusion that NFT-mediated stabilization of Nrf2 is a major contributor to its accumulation and the subsequent stimulation of GCL and glutathione synthesis

453,454,455,456,457,458 Autophagy also enhances osteoclastogenesis through an overactive autophagy-lysosomal system, facilitating cartilage erosion and bone destruction

doi:10.1001/jamainternmed.2019.1859