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Betaine Dietary Supplementation: Healthy Aspects in Human and Animal Nutrition Antioxidants , 2025

While NRF1 and NRF2 are differentially regulated by KEAP1 60 , both have overlapping targets and roles in preventing liver-related diseases 61

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Mammalian cell culture HEK293T (CRL-3216), THP-1 (TIB-202), U2OS (HTB-96), SUP-B15 (CRL-1929) and Jurkat (TIB-152) cell lines were obtained from ATCC

Notably, the Lys8 residue is highly conserved across all DHAR and CLIC proteins, but human omega GSTs contain a proline residue at this corresponding position, suggesting that omega GSTs may have different cysteine oxidation strategies 20 (Fig