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10.1007/s42535-022-00508-x 20 ChaudharyP.SinghD.SwapnilP.MeenaM.JanmedaP

They respond to sustained, daily support

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes Huang Y, He Y, Makarcyzk MJ, Lin H Frontiers in Bioengineering and Biotechnology (2021) This study demonstrated that FOXO4-DRI selectively removes senescent cells from human chondrocyte cultures expanded in vitro, providing direct evidence of the peptide's senolytic activity in human cells relevant to joint and cartilage aging

Protein reduction was performed with 10 mM DTT (Sigma-Aldrich) for 1 h at 37C

The median duration of NA therapy was 34.7 (interquartile range [IQR], 31.0-38.5) months and the majority (63.4%) of patients used entecavir