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Patients with certain FTO variants, for example, show accelerated hunger return after GLP-1 discontinuation and benefit from longer taper schedules and more intensive dietary intervention
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This consideration becomes less relevant as patients gain confidence and experience with self-administration
For others, it reduces the general reward response, making things that used to feel rewarding feel duller, which can appear as low mood or lack of interest
The evidence base is thinner than the popular discourse suggests
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