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They were exploring synthetic analogs of the peptide -MSH (alpha-melanocyte-stimulating hormone) a hormone that our bodies naturally produce to stimulate melanocytes, the pigmented cells in our skin and came up with melanotan I and II

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In contrast to IL-10, tumor necrosis factor induced protein 3 (TNFAIP3), also known as an anti-inflammatory protein (43), was already downregulated at 24 h and reached again the initial level at 14 d pi

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