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Moderate changes of the K m app values in combination with the altered k cat app values resulted in decreased apparent catalytic efficiencies of E170A/K for both substrates as compared with the wild-type enzyme and E170D (Fig

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These authors found that toxic IAPP oligomers initially appear within the granules in the secretory pathway, where they disrupt the membranes of the granules, leading to their release into the cytoplasm

Interferon regulatory factor 4 controls effector functions of CD8 + memory T cells

Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI