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To mitigate the risk of gastrointestinal disorders during the first months of treatment, the initial dose of semaglutide alone is 0.25 mg and may be increased every 4 weeks to 0.5, 1 and finally 2 mg, which is the maximum recommended dose [24]
It pairs that with a recommendation to monitor efficacy, tolerability and metabolic markers with a provider on a quarterly basis, and warns that cost savings should never override medical safety
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(6) Additionally, a protracted 16-week study posited a potential rise of up to 107% in growth hormone levels, accompanied by a corresponding increase in IGF-1 levels
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