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And per GLP-1 pharmacology, excess dietary carbohydrates can theoretically promote the insulin-secreting effects of GLP-1s which are not necessarily desirable
In addition, there was a lower incidence of nephropathy and a non-significantly higher incidence of retinopathy ( p = 0.33) in the liraglutide group in LEADER
The brain receptors, though less numerous than GLP-1 receptors, might contribute to metabolic regulation through central mechanisms
Keep your eyes peeled for: Proposed rule changes: There was a proposal to reinterpret the Medicare exclusion for anti-obesity drugs so that obesity itself (not just when comorbid with another condition) might be considered a medically accepted indication. But that change was not finalized in April 2025
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