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Kitano Y, Hashimoto S, Matsumoto H, et al

Two variants of Epac ( Epac1 and Epac2 ) are expressed in -cells, and downregulation of Epac function diminishes stimulatory effects of GLP-1 on -cell Ca 2+ signaling and insulin secretion

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8, 2023, the FDA approved Zepbound (tirzepatide) injection, the first and only obesity treatment of its kind that activates both GIP and GLP-1 hormone receptors