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PIF3 regulates anthocyanin biosynthesis in an HY5-dependent manner with both factors directly binding anthocyanin biosynthetic gene promoters in Arabidopsis
Cryo-EM structures of the active receptor with ghrelin and with the small-molecule agonist ibutamoren were published in Nature Communications, with coordinates including PDB 7W2Z, and a polar network plus a hydrophobic cluster have been implicated in both activation and the constitutive activity itself
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