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The 2025 IV pilot measured cardiac, hepatic, renal, thyroid, and glucose biomarkers and reported no abnormalities (Lee et al., 2025), which gives a sense of what those investigators considered worth checking

High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression

Non-Copper Approaches to Collagen Support If copper peptides specifically cause problems but other peptides suit you, consider collagen support through different pathways

While GHK-CU generally promotes healthy collagen remodeling, excessive MMP-1 activity can fragment healthy collagen before new collagen fully develops