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Ingested -carotene can be cleaved in the lumen of the intestine by either of two -carotene oxygenases (-carotene-15,15-monooxygenases) encoded by the BCO1 and BCO2 genes to yield two molecules of retinaldehyde (retinal)
Preclinical data also associate this signaling activity with lipolytic effects the mobilization of stored fat for use as an energy substrate which is one reason the compound appears in research examining body composition and metabolic regulation rather than muscle biology alone, a research area covered in more depth in our overview of the best peptides for fat loss
The primary treatment consists in regular injections of growth hormone, but because of needle pain and the considerable expense, researchers began to look for other ways to boost the levels of growth hormone in these children
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Proc Natl Acad Sci USA 1995
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