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In cases where the MIE is unknown or undefined, the earliest known KE in the chain (i.e., furthest upstream) should be used in lieu of the MIE and it should be made clear that the stated event is a KE and not the MIE

Elizabeth Rebello, one of the panelists, said during the first day of deliberation

GHK-Cu, a copper-binding tripeptide first isolated from human plasma by Pickart in 1973, is one of the most thoroughly studied peptides in skin biology, with published research demonstrating its influence on collagen synthesis, antioxidant enzyme regulation, and the expression of over 4,000 human genes

J.RauhM.BuchfelderM.et al (2017)

Many people enjoy a regular boost as part of a healthy routine