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307 , E928E934 (2014)

Biologic therapies effectively target specific inflammatory mediators, but do not directly address metabolic dysfunction or oxidative stress, both of which contribute to HS severity

Variability in response is expected and reflects differences in appetite biology, medication tolerance, lifestyle factors, and long-term adherence rather than medication choice alone

Graham Noctor, et al The glutathione system and its regulation by neurohormone melatonin in the central nervous system Cent Nerv Syst Agents Med Chem 2010 Dec 1