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GLP-1RAs were documented to normalise insulin resistance and modulate dopaminergic signalling reducing anhedonia and influencing food cue reactivity
Their work indicates that a significant reduction in melatonin levels, as observed in mice, increases hunger and leads to weight gain in two direct ways and one indirect way
Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis (ESSENCE)
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Science , 2022, 375: 12541261 Ruiz LM, Libedinsky A, Elorza AA
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