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In females, L2-Cmu mAb treatment led to a slight, albeit significant reduction in red blood cells (RBCs), hemoglobin (Hb), hematocrit (Hct), white blood cells (WBCs), lymphocytes (Supplementary Table 2), and serum phosphorus (Supplementary Table 3), though most values, with the exception of WBCs, remained within the normal range, and were less severely affected than previously reported with Ganitumab in young CD1 mice 26

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All compounds induced eryptosis, causing translocation of PS, increased levels of cytosolic calcium ions, and increased activation of caspase-3 and calpain in the human erythrocytes