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The Thr 7 forms a hyrogen bond with Lys197, while Asp9 forms a hydrogen bond with Arg380

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Scripps Clinic obesity and internal medicine specialist Mitch Biermann, MD, PhD, and Scripps Clinic internal medicine resident Michelle Wong, MD, report in the medical journal Obesity that most participants in their small clinical study sustained their peak weight loss from the popular medications even after reducing the dose frequency to once every two weeks and, for some patients, as infrequently as once every six weeks