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10.1016/S0893-133X(02)00306-8 97
G.BaborT
Schwingshackl L, Boeing H, Stelmach-Mardas M, Gottschald M, Dietrich S, Hoffmann G, et al
Our data from flow cytometry with annexin V/PI staining suggest that APAP and AZD3965 exert synergistic toxicity on HepG2 cells, particularly at high concentration, whereas, for example, treatment with 5 mM APAP led to a 27% reduction in cell viability compared to untreated controls and dosing with 1 M AZD3965 only led to a 7% reduction, the combination of the two resulted in a 55% reduction (Table 1)
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The standard 250-500 mcg per day remains appropriate
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