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These conformational changes are stabilized by additional noncovalent interactions involving the conserved residues, such as the Arg121 making hydrogen bonds with Asp67 to further strengthen the pi-cation interactions involving Trp72, Arg102, and Trp110 (see Figure 4 inset 2)
Point-of-care ultrasound (POCUS) is a validated and accurate technique that can be useful but requires additional training and expertise from anesthesiologists
Thus, hemoreactivity may depend more on drug fraction than liposome structure
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