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Agents that agonize glucagon-like peptide 1 receptors, including those that co-agonize other anorexigenic hormone receptors, lead to substantial weight loss and benefits in people with varying obesity-related complications, with further trials underway

Ferroptosis is caused by the reaction between iron and polyunsaturated fatty acids (PUFAs) to form membrane lipid peroxides (lipids containing unstable single-bonded oxygen atoms) that cause cell death