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SURMOUNT-5 actually showed lower GI-related discontinuation with tirzepatide (2.7%) than semaglutide (5.6%)
About 11.2% of participants discontinued due to side effects in clinical trials
The latter factor is able to interact with thioredoxin to reduce a specific cysteine (Cys-62) in the Rel-homology domain (RHD) of the NF-kB subunit p50 that had been previously oxidized by ROS 34 , restoring its ability to interact with specific responsive DNA sequences 35,36
This suggests that elevation of H 2 S alone is not sufficient to increase persulfide levels under these conditions
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