Anderson, 2006
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This led to Compound 13 (DNS-0056), a nanomolar (IC 50 : 26 nM), orally bioavailable (90%), and brain-penetrating (maximum brain plasma ratio: 1.7) PDE1B inhibitor with good memory-enhancing effects in the rat NOR test
Ici, nous rsumons les preuves actuelles sur la faon dont la dpltion en GSH et le dficit enzymatique li au GSH sont impliqus dans la pathologie des troubles crbraux tels que lautisme, la schizophrnie, le trouble bipolaire, la maladie dAlzheimer, et la maladie de Parkinson