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For researchers using IGF-1 LR3 as a tool to study these pathways, the practical advantage is that sustained receptor activation enables longer time-course studies of pathway dynamics

When ROCK is inhibited with Y-27632, it causes a redistribution of F-actin, leading to decreased nuclear localization of YAP and reduced expression of Cgtf and Cyr61

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Moreover, Cathepsin K (CTSK), a well-known key enzyme highly expressed in the bone resorption process in RA, was analyzed to mark the osteoclast differentiation